| Universal CPG from SAFC Proligo Reagents is truly universal as it can be employed in the synthesis of any oligonucleotide sequence instead of conventional nucleoside loaded CPG - whether loaded with adenosine, cytidine, guanosine or thymidine nucleosides. The use of universal CPG releases your resources as the purchase, handling and storage of differentially loaded types of nucleoside-CPG is no longer required. And 3’-end synthesis errors, because of accidental interchange of polymeric supports, are essentially eliminated. |
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| Key Features of Universal CPG |
| Fully compatible with standard phosphoramidite reagents and synthesis conditions |
| Can be employed in the synthesis of many different types of oligonucleotides: |
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DNA oligonucleotides |
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Phosphorothioates |
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2’O-Methyl oligonucleotides |
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Locked Nucleic Acid® (LNA®) oligonucleotides |
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Fluorescein, tetrachloro-fluorescein and biotin modifications |
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Particularly useful for high-throughput oligonucleotide synthesis |
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Coupling efficiency of ≥ 99.0% is routinely obtained |
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Convenient cleavage and deprotection |
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Avoids the use of unusual and potentially harmful reagents in the deprotection process e.g. heavy metals, sulfides |
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