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DNA Phosphoramidites

Proligo® Reagents

Product Breadth of Proligo Reagents
Standard Phosphoramidites
Green Arrow  DNA and RNA Pharmadite®
Green Arrow  DNA Phosphoramidite
Green Arrow  2'O-TC RNA Phosphoramidite
Green Arrow  2'O-TBDMS RNA Phosphoramidite
Green Arrow  2'O-Methyl Phosphoramidite
Green Arrow  2'Fluoro Phosphoramidite
Green Arrow  5'-NPPOC DNA Phosphoramidite
Green Arrow  Non-Standard Nucleosides Phosphoramidite

Fast Deprotection Chemistry (FD)
Green Arrow  FD DNA Phosphoramidite
Green Arrow  2'O-TBDMS RNA Phosphoramidite
Supports
Green Arrow  Bulk Controlled Pore Glass (CPG)
 DNA CPG
 RNA CPG
 Amino-ON CPG
 Universal CPG

Columns
Green Arrow  DNA CPG Column
Green Arrow  RNA CPG Column
Green Arrow  DNA Polystyrene Column
Labels and Modifications
Green Arrow  6-FAM
Green Arrow  Fluorescein Phosphoramidite
Green Arrow  Biotin Phosphoramidite
Green Arrow  Phosphate-ON

Linkers
Green Arrow  MMT and TFA Amino Linker
Green Arrow  ssH Linker

Solvents
Green Arrow  Liquid Reagents
Green Arrow  Activator 42®

Highest Quality

SAFC Proligo Reagents’ world-class expertise in nucleic acid synthesis began in 1983 when Dr. Hubert Köster first commercialized the synthesis of β-cyanoethylphosphoramidites. Since then, the company has refined and perfected the production of DNA and RNA phosphoramidites. Today, SAFC Proligo Reagents® offers the highest quality phosphoramidites in the industry.

Key Features of DNA Phosphoramidites


Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib))

Recommended cleavage and deprotection conditions are 8 hours at 55°C or 24 hours at room temperature using concentrated ammonia solution, for standard baseprotected oligonucleotides

The high coupling efficiency of Proligo Reagents’ DNA phosphoramiditesleads to high-yield, high-quality oligonucleotides
 
  Download Literature:
  •  Download the Proligo Reagents catalog
  •  User Instructions
Pharmadite
(217k pdf)
  View Structure:
  •  DMT-dA(bz)
Pharmadite
  •  DMT-dC(bz)
Pharmadite
  •  DMT-dG(ib)
Pharmadite
  •  DMT-dT Pharmadite

Standard DNA Phosphoramidites
Compatible with Expedite™ and Polygen® Instruments
Product No. Description Unit
A111081-12 DMT-dA(bz) amidite 12 × 1 g
A111082-12 DMT-dA(bz) amidite 12 × 2 g
C111081-12 DMT-dC(bz) amidite 12 × 1 g
C111082-12 DMT-dC(bz) amidite 12 × 2 g
G111081-12 DMT-dG(ib) amidite 12 × 1 g
G111082-12 DMT-dG(ib) amidite 12 × 2 g
T111081-12 DMT-dT amidite 12 × 1 g
T111082-12 DMT-dT amidite 12 × 2 g
Standard DNA Phosphoramidites
Compatible with ABI™ Instruments
Product No. Description Unit
A111031-12 DMT-dA(bz) amidite 12 × 1 g
C111031-12 DMT-dC(bz) amidite 12 × 1 g
G111031-12 DMT-dG(ib) amidite 12 × 1 g
T111031-12 DMT-dT amidite 12 × 1 g
A111032-12 DMT-dA(bz) amidite 12 × 2 g
C111032-12 DMT-dC(bz) amidite 12 × 2 g
G111032-12 DMT-dG(ib) amidite 12 × 2 g
T111032-12 DMT-dT amidite 12 × 2 g
A111064-12 DMT-dA(bz) amidite 12 × 4 g
C111064-12 DMT-dC(bz) amidite 12 × 4 g
G111064-12 DMT-dG(ib) amidite 12 × 4 g
T111064-12 DMT-dT amidite 12 × 4 g
Compatible with Mermade™ Instruments (8oz 28/400 bottle)
Product No. Description Unit
A111085-06 DMT-dA(bz) amidite 6 × 5 g
C111085-06 DMT-dC(bz) amidite 6 × 5 g
G111085-06 DMT-dG(ib) amidite 6 × 5 g
T111085-06 DMT-dT amidite 6 × 5 g
A111028-06 DMT-dA(bz) amidite 6 × 10 g
C111028-06 DMT-dC(bz) amidite 6 × 10 g
G111028-06 DMT-dG(ib) amidite 6 × 10 g
T111028-06 DMT-dT amidite 6 × 10 g
Compatible with AKTA™ Oligo Pilot Instruments (100ml septum bottle)
Product No. Description Unit
A111005-01 DMT-dA(bz) amidite 5 g
A111005-06 DMT-dA(bz) amidite 6 × 5 g
A111010-01 DMT-dA(bz) amidite 10 g
A111020-06 DMT-dA(bz) amidite 6 × 20 g
C111005-01 DMT-dC(bz) amidite 5 g
C111005-06 DMT-dC(bz) amidite 6 × 5 g
C111010-01 DMT-dC(bz) amidite 10 g
C111020-06 DMT-dC(bz) amidite 6 × 20 g
G111005-01 DMT-dG(ib) amidite 5 g
G111005-06 DMT-dG(ib) amidite 6 × 5 g
G111010-01 DMT-dG(ib) amidite 10 g
G111020-06 DMT-dG(ib) amidite 6 × 20 g
T111005-01 DMT-dT amidite 5 g
T111005-06 DMT-dT amidite 6 × 5 g
T111010-01 DMT-dT amidite 10 g
T111020-06 DMT-dT amidite 6 × 20 g
Bulk Quantities (16oz 28/400 bottle)
Product No. Description Unit
A111005-01 DMT-dA(bz) amidite 5 g
A111005-06 DMT-dA(bz) amidite 6 × 5 g
A111010-01 DMT-dA(bz) amidite 10 g
A111020-06 DMT-dA(bz) amidite 6 × 20 g
C111005-01 DMT-dC(bz) amidite 5 g
C111005-06 DMT-dC(bz) amidite 6 × 5 g
C111010-01 DMT-dC(bz) amidite 10 g
C111020-06 DMT-dC(bz) amidite 6 × 20 g
G111005-01 DMT-dG(ib) amidite 5 g
G111005-06 DMT-dG(ib) amidite 6 × 5 g
G111010-01 DMT-dG(ib) amidite 10 g
G111020-06 DMT-dG(ib) amidite 6 × 20 g
T111005-01 DMT-dT amidite 5 g
T111005-06 DMT-dT amidite 6 × 5 g
T111010-01 DMT-dT amidite 10 g
T111020-06 DMT-dT amidite 6 × 20 g
Custom Products Bulk packaging up to multiple kg per container and customized packaging
with alternative quantities of amidites are available upon request.

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