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2'O-TC RNA Phosphoramidite

Proligo® Reagents

Product Breadth of Proligo Reagents
Standard Phosphoramidites
Green Arrow  DNA and RNA Pharmadite®
Green Arrow  DNA Phosphoramidite
Green Arrow  2'O-TC RNA Phosphoramidite
Green Arrow  2'O-TBDMS RNA Phosphoramidite
Green Arrow  2'O-Methyl Phosphoramidite
Green Arrow  2'Fluoro Phosphoramidite
Green Arrow  5'-NPPOC DNA Phosphoramidite
Green Arrow  Non-Standard Nucleosides Phosphoramidite

Fast Deprotection Chemistry (FD)
Green Arrow  FD DNA Phosphoramidite
Green Arrow  2'O-TBDMS RNA Phosphoramidite
Supports
Green Arrow  Bulk Controlled Pore Glass (CPG)
 DNA CPG
 RNA CPG
 Amino-ON CPG
 Universal CPG

Columns
Green Arrow  DNA CPG Column
Green Arrow  RNA CPG Column
Green Arrow  DNA Polystyrene Column
Labels and Modifications
Green Arrow  6-FAM
Green Arrow  Fluorescein Phosphoramidite
Green Arrow  Biotin Phosphoramidite
Green Arrow  Phosphate-ON

Linkers
Green Arrow  MMT and TFA Amino Linker
Green Arrow  ssH Linker

Solvents
Green Arrow  Liquid Reagents
Green Arrow  Activator 42®

SAFC TC RNA Phosphoramidites

SAFC extends its robust Proligo® Reagents portfolio with the new TC RNA Phosphoramidite product line. Developed by Agilent Technologies and distributed through SAFC, these highly regarded, innovative monomers allow for faster, more efficient RNA based oligo manufacturing and the potential to build longer RNA oligos (>100 bases). TC RNA Phosphoramidites streamline the deprotection process resulting in consistently high quality products, offering time and cost savings.



Key Features of 2'O-TC RNA Phosphoramidites
Reduced coupling time 3 minutes with ETT Activator 0.25M compared to 15 minutes of TBDMS RNA
High coupling efficiency
One-step downstream process with neat Ethylenediamine
Cleavage and deprotection within 2hours at ambient temperature
No need of any fluoride component
No need for desalting of oligos required
Enables manufacturing of long RNA oligomers
High yields of final oligo, best results have been archived using a buffer system


TC RNA Phosphoramidites Structures

SAFC is committed to this technology and provides these Phosphoramidites at unequalled purity and quality.

Ordering Information
 TC RNA Phosphoramidites
 Compatible with ABI™/ÄKTA®
Product No. Description Unit
A211630-0.5G DMT-2'O-TC-rA(bz) Phosphoramidite 1 x 0.5G
C213630-0.5G DMT-2'O-TC-rC(ac) Phosphoramidite 1 x 0.5G
G211630-0.5G DMT-2'O-TC-rG(ib) Phosphoramidite 1 x 0.5G
U211630-0.5G DMT-2'O-TC-rU Phosphoramidite 1 x 0.5G
A211630-1G DMT-2'O-TC-rA(bz) Phosphoramidite 1 x 1G
C213630-1G DMT-2'O-TC-rC(ac) Phosphoramidite 1 x 1G
G211630-1G DMT-2'O-TC-rG(ib) Phosphoramidite 1 x 1G
U211630-1G DMT-2'O-TC-rU Phosphoramidite 1 x 1G
 Compatible with Expedite™
A211680-0.5G DMT-2'O-TC-rA(bz) Phosphoramidite 1 x 0.5G
C213680-0.5G DMT-2'O-TC-rC(ac) Phosphoramidite 1 x 0.5G
G211680-0.5G DMT-2'O-TC-rG(ib) Phosphoramidite 1 x 0.5G
U211680-0.5G DMT-2'O-TC-rU Phosphoramidite 1 x 0.5G
A211680-1G DMT-2'O-TC-rA(bz) Phosphoramidite 1 x 1G
C213680-1G DMT-2'O-TC-rC(ac) Phosphoramidite 1 x 1G
G211680-1G DMT-2'O-TC-rG(ib) Phosphoramidite 1 x 1G
U211680-1G DMT-2'O-TC-rU Phosphoramidite 1 x 1G
 Compatible with MerMade
Product No. Description Unit
A211640-1G DMT-2'O-TC-rA(bz) Phosphoramidite 1 x 1G
C213640-1G DMT-2'O-TC-rC(ac) Phosphoramidite 1 x 1G
G211640-1G DMT-2'O-TC-rG(ib) Phosphoramidite 1 x 1G
U211640-1G DMT-2'O-TC-rU Phosphoramidite 1 x 1G

TC RNA phosphoramidites and it use is protected by pending US Patent applications Nos. 12/118,655; 12/466326; 61/099,131 and corresponding foreign counterparts, including those issuing from PCT/US08/63342 and PCT/US09/057922. A license may be required.

SAFC and Proligo are registered trademarks of Sigma-Aldrich Co. LLC.
©2012 Sigma-Aldrich Co. LLC. All rights reserved. Reproduction forbidden without permission.
Other trademarks are the property of their respective owners.

To order or speak with a Customer Service Representative, contact your local SAFC office.