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Biocides & Preservatives

Diagnostics Product Group
ProClin® Preservatives:
   Key features of ProClin Preservatives
   Mechanism of Action
   ProClin Evaluation Kits & Packaging
   ProClin Features
   ProClin Preservatives Product List
   Sodium Azide Product List
   ProClin Product Information

ProClin preservatives are an excellent choice for replacing thimerosal, sodium azide and gentamicin preservatives. In addition they are highly effective, broad-spectrum biocides for controlling microorganisms in reagents and products intended for in vitro diagnostics use. At concentrations as low as 0.02%, these preservatives eradicate bacteria, fungi and yeast for extended periods of time.


View our recent article in Specialty Chemicals Magazine discussing the critical role of IVD preservatives from an environmental perspective.



Krebs Cycle
Key features of ProClin preservatives
Compatibility with key enzymes and assay indicators
Will not inhibit antibody binding
Easy-to-use water-soluble liquid, effective at very low concentrations
Excellent stability over a wide pH range
Level of active ingredients assayable by HPLC (Inquire for a HPLC standard)
At recommended usage levels, ProClin presents no health hazards, toxological problems or disposal issues
 

Mechanism of Action
The active components of ProClin are three isothiazolones, 2-Methyl-4-isothiazolin-3-one, 5-Chloro-2-methyl-4-isothiazolin-3-one and 1,2-Benzisothiazolin-3-one.

Within minutes of contacting a microorganism, the active components penetrate the cell wall and inhibit specific enzymes (at the points noted in red in the Krebs Cycle).

Growth, macromolecule synthesis and respiration are inhibited, ultimately leading to cell death.





ProClin Evaluation Kits
ProClin Evaluation Kits are available for determining the suitability of ProClin products in new product development. Each evaluation kit contains three different manufactured lots of ProClin for testing performance consistency from lot to lot.

To determine the appropriate ProClin product for a specific application, ProClin variety kits are also available. Each kit contains 5 mL of Proclin 150, 200, 300 and 950.
ProClin Evaluation Kits
33360-U ProClin Reference Standard - 1 mL ampule (1.5% A.I. solution)
48121 ProClin 150 – 3 x 5 mL (3 lot numbers)
49381-U ProClin 150 – 3 x 400 mL (3 lot numbers)
48911-U ProClin 300 – 3 x 5 mL (3 lot numbers)
48119-U ProClin Variety Kit – 5 mL each of ProClin 150, 200, 300 & 950 as an aid to select the appropriate ProClin product for a specific application
ProClin Features
Features ProClin B-119 ProClin 150 ProClin 200 ProClin 300 ProClin 950
Active (A.I.) BIT CMIT/MIT CMIT/MIT CMIT/MIT MIT
% total A.I. 18.8 – 19.9 1.5 1.5 3 9.5
Stabilizers none 23 – 25% Mg salts 3% Mg & Cu salts Alkyl Carboxylate none
Matrix Dipropylene Glycol (60%)
Water (15%)
Sodium Hydroxide (6%)
Water Water Propylene Glycol Water
Working pH Range 4 – 12 2.5 – 8.5 2.5 – 8.5 2.5 – 8.5 2 – 12
Typical Dosage Levels
(w/w)
0.05 – 0.15% 0.05 – 0.10% 0.05 – 0.10% 0.03 – 0.05% 0.05 – 0.10%
Specific Gravity 1.14 1.20 1.02 1.03 1.02
Shelf Life 2 years 4 years 18 months 3 years 3 years



ProClin Preservatives Product List
Description Catalog No.  
ProClin B-119 Preservative
50 mL bottle 40424-U
400 mL bottle 40425-U
ProClin 150 Preservative
50 mL bottle 49376-U
400 mL bottle 49377-U
3.6 L bottle 49378-U
15 L pail 49379-U
110 kg drum (91.7 L) 49380-U
ProClin 200 Preservative
50 mL bottle 48171-U
400 mL bottle 500380
3.6 L bottle 500399
15 L pail 500402
ProClin 300 Preservative
1 x 5 mL vial 48934-U
50 mL bottle 48912-U
400 mL bottle 48914-U
2.0 L bottle 48915-U
3.6 L bottle 48917-U
18 L pail 48918-U
110 kg drum (107.8 L) 48919-U
ProClin 950 Preservative
5 mL ampule 46885-U
50 mL bottle 46878-U
400 mL bottle 46879-U
3.6 L bottle 46883-U
17 L pail 46884-U
 
Sodium Azide Product List
Description Catalog No.  
SigmaUltra S8032
ReagentPlus®, ≥99.5% S2002
purum p.a., ≥99.0% (T) 71290

 

ProClin Product Information
ProClin B-119
ProClin B-119 – Product Information (MPX) (225 Kb PDF)
ProClin 150
ProClin 150 – Product Information (KVK) (552 Kb PDF)
ProClin 150 & 300 – Determination of ppm Level (KVU) (119 Kb PDF)
ProClin 150 – Stability & Storage (KVH) (643 Kb PDF)
ProClin 200
ProClin 200 – Product Information (KVM) (549 Kb PDF)
ProClin 300
ProClin 300 – Product Information (KVO) (770 Kb PDF)
ProClin 300 – Features & Benefits (KVS) (6.63 Mb PDF)
ProClin 150 & 300 – Determination of ppm Level (KVU) (119 Kb PDF)
ProClin 950
ProClin 950 – Product Information (KVQ) (495 Kb PDF)
ProClin 950 – Directions for Use (LLZ) (448 Kb PDF)


Application and Handling Information
ProClin – Efficacy versus Thimerosal and Sodium Azide (JEX) (188 Kb PDF)
ProClin – Efficacy Tests (KVT) (145 Kb PDF)
ProClin – Mechanisms & Stability (KVV) (4.5 Mb PDF)
ProClin – Product Flyer (JRG) (726 Kb PDF)
ProClin 150, 200, 300 – General Safety & Handling (KVL) (535 Kb PDF)
ProClin 950 – General Safety & Handling (KVR) (217 Kb PDF)
For further information or to obtain a preservative efficacy study performed by an independent laboratory, contact your SAFC representative.

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