> Overview > Complex Technologies > Large Molecule Biologics > Complex Technologies Bioconjugation Fermentation Potent Fermentation Fill / Finish Protein Purification Bio-organic Custom APIs, Excipients and Adjuvants Viral Vectors/Vaccines > Services Overview Manufacturing Facilities Request Information > Small Molecule APIs

Natural and Recombinant Protein Complex Technologies Large-Scale Purification of Natural and Recombinant Proteins Proteins derived from natural plant and animal-based sources are becoming increasingly important components in the manufacture of key biologic drugs. SAFC Pharma® has purpose built facilities that can process multi-tons of biomass, producing up to 6.5 kg of purified biological protein products per week. With over 30 years experience in manufacturing biologics materials, the company is at the leading edge in supporting commercial biologics projects from clinical trials all the way through commercialization. Purification Process Capabilities   Large, Class 100,000 (ISO 8) and Class 10,000 (ISO 7) suites   Suites capable of 1.5 m column chromatography   Unidirectional personnel and material flows   Clinical to commercial capabilities   Proteins, adjuvants, and excipients product expertise   Delta-V digital system control   200 L Lyophilization capacity Downstream Purification of Microbial or Yeast-based Proteins Microbial, yeast or fungal-based fermentation products, manufactured by SAFC Pharma or by third parties can take advantage of St. Louis purification facilities   US based purification complements strategic stockpile projects   Minimizes the typical delays expected in the purification process Purification of Plant-Based Proteins Our purification facility has the capability to add extraction processes to the purification scheme.   Up to 5,000 kg of plant-based biomass and 6.5 kg of therapeutic protein can be processed per week   Completely animal-free raw materials facility   Three large 2,500 L tanks for semi-continuous extraction enables high throughput Purification of Animal-Based Proteins Separate animal-based facility offers similar purification scales dedicated to the extraction and purification of animal-sourced products.   Class 100,000 (ISO 8) and Class 10,000 (ISO 7) suites   Modern purification equipment and processes Request Information