Potent Fermentation

SAFC^®

Highly Potent Bacterial and Fungal Fermentation

The company, through its Sigma-Aldrich® owners, has built its expertise in fermentation derived products for over 30 years.

Combining its exceptional expertise in small molecule chemistry, biologics and highly-potent compound handling, SAFC offers unique large-scale fermentation-based high-potent API manufacturing through its Jerusalem (Israel) manufacturing facility to help customers bring exciting new drugs to market.

Microbial fermentation is necessary for manufacturing such pharmaceutical and biopharmaceutical actives as small organic molecules, proteins, cell wall components (e.g. Lipopolysaccharides, Lipid A) and DNAs. Product diversity makes fermentation technology a multi-disciplinary expertise associated with microbiology, organic chemistry, biochemistry and molecular biology. Another level of complexity is revealed upon Biosafety Level 2 Large Scale (BSL2-LS) fermentation utilizing Risk Group 2 (RG2) pathogens, and occasionally processing in explosion proof environments.

Capabilities
	Biosafety Level 2 Large Scale (BSL2-LS) bacterial and fungal fermentation
	19 Liter, 100 Liter, 1,000 Liter and 4,000 Liter fermentors
	Handling of human pathogens up to Risk Group 2 (RG2)
	Large Scale recovery and downstream processing including an explosion proof environment
	Final purification automated equipment
	Planned certification for HPAPIs
	Stringent segregation and containment design

>> For more information view the High Potent Fermentation Insert (278 Kb PDF)

>> Additional Fermentation Capabilities

>> View the Israel Facility

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