Targeted Drug Delivery through Bioconjugation

Complex Emerging Technologies

High Potent Bio-conjugation process scheme

Targeted Drug Delivery Through Bioconjugation

Antibody-drug conjugation technology uses monoclonal antibodies or other biologics to deliver conjugated highly-potent APIs (HPAPIs) to targeted cells. In conjugated form, the HPAPI exhibits more selective cytotoxicity, thereby, sparing non-target cells from many of the toxic effects.

For antibody drug conjugates (ADCs), SAFC® can conjugate biological molecules with high-potent APIs (HPAPIs) to meet pharmaceutical industry demands for development of new oncology products that are more targeted and exponentially more powerful.

Bioconjugation Capabilities
Often cytotoxic or neurotoxic, HPAPIs must be managed with the highest level of containment. SAFC facilities incorporate appropriate room pressurization, airlocks, ventilation and isolators to ensure proper handling of these highly-potent materials within cGMP suites designed especially for biologics manufacturing process:

	SAFC manufactured HPAPIs
	Traditional (non-potent) APIs from SAFC or the customer
	SAFC or customer manufactured linkers with unique conjugation properties
	Proven and experienced quality assurance oversight for HPAPIs
	Clinical trials APIs manufactured to ICH Q7A guidelines
	Conjugation for linking of non-potent APIs to other biologic carriers, including polyamino acids or polynucleotides

Pfēnex Expression Technology™ platform

SAFC partners with Pfēnex Inc. to provide customers with a cutting-edge expression technology system. With SAFC’s world-class contract manufacturing services and purpose-built facilities, the partnership facilitates a more comprehensive offering in the area of vaccine components and support development of conjugate vaccines. The Pfēnex expression technology also aids in the production of fermentation-derived recombinant proteins. To learn more about SAFC’s partnership with Pfēnex, click here: Pfēnex Expression Technology platform.

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