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Cell Design Studio
 SAFC® recognizes the need for biopharmaceutical customers to create robust, efficient cell lines — often a time-consuming and costly endeavor. More efficient cell lines can significantly reduce production costs. Outsourcing the engineering of production cell lines allows biopharmaceutical companies to focus their R&D efforts on developing new therapeutics.
The Cell Design Studio team is familiar with the needs and concerns specific to biopharmaceutical customers. This service includes:
| Project management support from inquiry to project completion |
| Documentation of cell handling and full traceability of raw materials |
Service offering specific to biopharmaceutical customers:
| Engineering of production cell lines using Zinc Finger Nucleases (ZFNs) |
| Identification of integration sites of recombinant genes in CHO cells for evaluation as "hot spots" |
| Design and application of custom shRNAs to validate potential engineering targets in production cell lines |
Examples of potential cell engineering projects include:
| Creating new CHO parental lines with increased culture longevity or engineering metabolic selection systems to increase productivity |
| Improving therapeutic efficacy by altering glycosylation pathways |
| Removing endogenous proteins to simplify downstream purification |
| Eliminate viral components in host cell |
| Targeted integration of recombinant genes into "hot spots" |
| Sequencing of CHO genes to facilitate ZFN design |
| Development of production cell lines using SAFC platform cell lines and expression systems |
New CHOZN® ZFN-Modified CHO Cell Lines
SAFC is proud to offer a newly created series of zinc finger nuclease (ZFN) modified CHO cell lines with characteristics that are attractive in a platform cell line to biopharmaceutical developers and manufacturers. Learn more here about these novel cell lines and find out how they can you take your molecule to clinic faster.
» Interested in Cell Design Studio? Or do you have a question?
Complete our Contact / Inquiry Form and we will quickly provide you with the information you're looking for.
» Or go to our SAFC Office Locations page for site specific addresses & phone numbers. |
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